The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis

The thyroid receptor interacting protein-6 (TRIP6) was first identified as a ligand-dependent binding partner for the thyroid hormone receptor in a yeast two-hybrid screen. A partial TRIP6 cDNA clone that was isolated in the initial screen encodes two copies of the LIM domain. The LIM domain is a do...

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Bibliographic Details
Published inGenomics (San Diego, Calif.) Vol. 49; no. 2; pp. 314 - 316
Main Authors JINSEONG YI, BECKERLE, M. C
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier 15.04.1998
Subjects
Adaptor Proteins, Signal Transducing
Amino Acid Sequence
ATPases Associated with Diverse Cellular Activities
Biological and medical sciences
Chromosome Mapping
Chromosomes, Human, Pair 7 - genetics
Cytoskeletal Proteins
Fundamental and applied biological sciences. Psychology
Genes, Tumor Suppressor
Genes. Genome
Glycoproteins
Homeodomain Proteins - genetics
Humans
LIM Domain Proteins
Metalloproteins - genetics
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Proteasome Endopeptidase Complex
Proteins - genetics
Transcription Factors - genetics
Zyxin
Genetic mapping
Human
Nucleotide sequence
Homology
Chromosome C7
Carcinogenesis
Binding protein
LIM domain
Gene
Domain structure
Thyroid hormone
Molecular biology
Hormonal receptor
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Summary:The thyroid receptor interacting protein-6 (TRIP6) was first identified as a ligand-dependent binding partner for the thyroid hormone receptor in a yeast two-hybrid screen. A partial TRIP6 cDNA clone that was isolated in the initial screen encodes two copies of the LIM domain. The LIM domain is a double zinc-finger structure that mediates protein-protein interactions. Here we report the complete amino acid sequence of human TRIP6. The TRIP6 protein displays a proline-rich N-terminal region linked to three tandemly arrayed C-terminal LIM domains. The global molecular architecture and sequence of TRIP6 place it in the same family as the adhesion plaque protein, zyxin, and the lipoma preferred partner (LPP). Zyxin and LPP are implicated in cellular signaling and tumorigenesis, respectively. By radiation hybrid mapping, the human TRIP6 gene was assigned to a segment of chromosome 7q22 that is commonly deleted in malignant myeloid diseases and uterine leiomyoma.
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ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1998.5248