Helicobacter pylori infection and blood group antigens: lack of clinical association

Blood group antigens traditionally have been associated with a risk of developing peptic ulcer and gastric cancer. Helicobacter pylori is a bacterium associated with chronic active gastritis and ulcer disease, and its attachment to gastric mucosa was recently shown in vitro to be mediated by blood g...

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Published inThe American journal of gastroenterology Vol. 91; no. 10; p. 2135
Main Authors Umlauft, F, Keeffe, E B, Offner, F, Weiss, G, Feichtinger, H, Lehmann, E, Kilga-Nogler, S, Schwab, G, Propst, A, Grussnewald, K, Judmaier, G
Format Journal Article
LanguageEnglish
Published United States 01.10.1996
Subjects
Biopsy
Blood Group Antigens
Case-Control Studies
Chi-Square Distribution
Cluster Analysis
Endoscopy, Gastrointestinal
Female
Gastric Mucosa - pathology
Gastritis - blood
Gastritis - microbiology
Helicobacter Infections - blood
Helicobacter Infections - diagnosis
Helicobacter Infections - epidemiology
Helicobacter pylori
Humans
Logistic Models
Male
Middle Aged
Peptic Ulcer - blood
Peptic Ulcer - microbiology
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Summary:Blood group antigens traditionally have been associated with a risk of developing peptic ulcer and gastric cancer. Helicobacter pylori is a bacterium associated with chronic active gastritis and ulcer disease, and its attachment to gastric mucosa was recently shown in vitro to be mediated by blood group Lewisb and H antigens. This study was designed to test the clinical relevance of this laboratory observation in patients undergoing endoscopy and gastric biopsy. Blood group phenotypes and gastric biopsies for H. pylori and histology were determined and correlated in 384 patients undergoing upper endoscopy. Blood from healthy blood donors was tested for the same blood group antigens and used as a control group. The distribution of blood groups ABO, Lewis, Rhesus, and MN was similar among the patients undergoing endoscopy and a control group of 2369 healthy blood donors from the same geographic area. There was no correlation between H. pylori infection or the H. pylori-associated diseases, peptic ulcer or chronic active gastritis, with any blood group phenotype, including Lewisb, blood group O, or both. No in vivo correlation between H. pylori infection or disease and Lewisb or H antigen could be demonstrated. Moreover, patients with H. pylori infection and disease have a distribution of blood group antigens similar to a control population.
ISSN:0002-9270