Synthesis and structure elucidation of some 4-substituted benzylidene amino-5-[3(5)-methyl-5(3)-phenyl-1H-1-pyrazolyl]-2,4-dihydro-3H-1,2,4- triazole-3-thione derivatives with their antimicrobial activities

A new series of 4-substituted benzylideneamino-5[3(5)-methyl-5(3)-phenyl-1H-1-pyrazolyl]-2 ,4-dihydro-3H- 1,2,4-triazole-3-thione was synthesized by reaction of I with suitable aldehyde and tested for their antimicrobial activities against six microorganisms. Most of the compounds showed antibacteri...

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Published inFarmaco (Società chimica italiana : 1989) Vol. 52; no. 8-9; p. 565
Main Authors Doğan, H N, Büyüktimkin, S, Rollas, S, Yemni, E, Cevikbaş, A
Format Journal Article
LanguageEnglish
Published France 01.08.1997
Subjects
Anti-Bacterial Agents
Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - pharmacology
Benzylidene Compounds - chemical synthesis
Benzylidene Compounds - pharmacology
Chemical Phenomena
Chemistry, Physical
Fungi - drug effects
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Pyrazoles - chemical synthesis
Pyrazoles - pharmacology
Structure-Activity Relationship
Thiones - chemical synthesis
Thiones - pharmacology
Triazoles - chemical synthesis
Triazoles - pharmacology
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Summary:A new series of 4-substituted benzylideneamino-5[3(5)-methyl-5(3)-phenyl-1H-1-pyrazolyl]-2 ,4-dihydro-3H- 1,2,4-triazole-3-thione was synthesized by reaction of I with suitable aldehyde and tested for their antimicrobial activities against six microorganisms. Most of the compounds showed antibacterial activity against Gram positive bacteria.
ISSN:0014-827X
1879-0569