Gene therapy in transplantation

The success of gene therapy in clinical transplantation depends largely on the further development of appropriate expression vectors. Currently available vectors all suffer from significant disadvantages. New vectors must overcome problems associated with lack of specific cell targeting in vivo, low...

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Bibliographic Details
Published inThe Journal of heart and lung transplantation Vol. 15; no. 9; p. 857
Main Author Hullett, D A
Format Journal Article
LanguageEnglish
Published United States 01.09.1996
Subjects
Animals
Diabetes Mellitus, Experimental - surgery
Gene Expression Regulation
Genes, Reporter
Genetic Therapy - methods
Genetic Vectors
Graft Rejection - immunology
Graft Rejection - prevention & control
Humans
Islets of Langerhans Transplantation
Organ Transplantation
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Summary:The success of gene therapy in clinical transplantation depends largely on the further development of appropriate expression vectors. Currently available vectors all suffer from significant disadvantages. New vectors must overcome problems associated with lack of specific cell targeting in vivo, low transfection frequencies, and lack of long-term stable expression. Despite these problems, the results obtained in animal models show the potential of gene therapy techniques to modulate immune responses, enhance graft function, and correct genetic disorders.
ISSN:1053-2498