Longitudinal analysis of HLA associated risks for iridocyclitis in juvenile rheumatoid arthritis

The risk of iridocyclitis in children with early onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA) has been shown to be associated with certain HLA haplotypes. Our report contains an actuarial analysis, using one-year intervals, of 161 subjects and estimates haplotype specific risks. Ind...

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Bibliographic Details
Published inJournal of rheumatology Vol. 18; no. 9; p. 1394
Main Authors Giannini, E H, Malagon, C N, Van Kerckhove, C, Taylor, J, Lovell, D J, Levinson, J E, Passo, M H, Ginsberg, J, Burke, M J, Glass, D N
Format Journal Article
LanguageEnglish
Published Canada 01.09.1991
Subjects
Adolescent
Arthritis, Juvenile - complications
Arthritis, Juvenile - genetics
Child
Child, Preschool
Disease Susceptibility
Female
Gene Frequency - genetics
Haplotypes - genetics
Histocompatibility Antigens Class II - genetics
Histocompatibility Antigens Class II - physiology
Humans
Iridocyclitis - epidemiology
Iridocyclitis - etiology
Iridocyclitis - genetics
Life Tables
Longitudinal Studies
Male
Risk Factors
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Summary:The risk of iridocyclitis in children with early onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA) has been shown to be associated with certain HLA haplotypes. Our report contains an actuarial analysis, using one-year intervals, of 161 subjects and estimates haplotype specific risks. Individuals who possess the major susceptibility haplotype HLA-DR5 (11) developed eye disease earlier and with a greater frequency than did those with the protective HLA-DR1 haplotype. Highly significant differences were found between the resulting life-table curves for HLA-DR5 and HLA-DR1 positive subjects (p = 0.00003). These time oriented risk estimates may aid clinicians in determining more precisely the probability of iridocyclitis throughout the course of the disease in children with EOPA-JRA.
ISSN:0315-162X
1499-2752