Coumarin necrosis--a review of the literature

Skin and soft tissue necrosis is a rare complication of anticoagulation therapy. Two patients who exhibited the spectrum of this disorder are described. The clinical features, etiology, pathophysiology, and treatment of coumarin skin necrosis are outlined, and the English-language literature is revi...

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Bibliographic Details
Published inSurgery Vol. 103; no. 3; p. 271
Main Authors Cole, M S, Minifee, P K, Wolma, F J
Format Journal Article
LanguageEnglish
Published United States 01.03.1988
Subjects
Adult
Aged
Coumarins - adverse effects
Ecchymosis - chemically induced
Female
Hemorrhage - chemically induced
Humans
Male
Middle Aged
Necrosis - chemically induced
Purpura - chemically induced
Thrombophlebitis - drug therapy
Warfarin - adverse effects
Warfarin - therapeutic use
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Summary:Skin and soft tissue necrosis is a rare complication of anticoagulation therapy. Two patients who exhibited the spectrum of this disorder are described. The clinical features, etiology, pathophysiology, and treatment of coumarin skin necrosis are outlined, and the English-language literature is reviewed.
ISSN:0039-6060