Systemic lupus erythematosus: calciphylaxis induced cardiomyopathy

A 31-year-old woman with systemic lupus erythematosus (SLE), diabetes mellitus, and chronic renal failure developed digital ischemia, myocardial dysfunction, abnormal ECG, and elevated CPK levels. Radiographic studies revealed calcification of the peripheral vasculature although coronary angiography...

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Bibliographic Details
Published inJournal of rheumatology Vol. 22; no. 1; p. 177
Main Authors MacLean, C, Brahn, E
Format Journal Article
LanguageEnglish
Published Canada 01.01.1995
Subjects
Adult
Biopsy
Calciphylaxis - diagnostic imaging
Calciphylaxis - etiology
Calciphylaxis - pathology
Calciphylaxis - therapy
Cardiomyopathies - etiology
Cardiomyopathies - pathology
Female
Humans
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - pathology
Myocardium - pathology
Parathyroid Glands - surgery
Radiography
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Summary:A 31-year-old woman with systemic lupus erythematosus (SLE), diabetes mellitus, and chronic renal failure developed digital ischemia, myocardial dysfunction, abnormal ECG, and elevated CPK levels. Radiographic studies revealed calcification of the peripheral vasculature although coronary angiography was unremarkable. An endomyocardial biopsy demonstrated intra and extracellular myocardial calcification without evidence of vasculitis or primary myocarditis. A diagnosis of calciphylaxis, as a result of secondary hyperparathyroidism, was made. This case demonstrates that calciphylaxis can mimic the cardiovascular manifestations of SLE. Early differentiation of these disparate diseases is important because treatment strategies employed in SLE may exacerbate calciphylaxis.
ISSN:0315-162X