The Vin-1 gene, identified by provirus insertional mutagenesis, is the cyclin D2

• Published in: Oncogene Vol. 8; no. 6; p. 1661
• Main Authors: Hanna, Z, Jankowski, M, Tremblay, P, Jiang, X, Milatovich, A, Francke, U, Jolicoeur, P
• Format: Journal Article
• Language: English
• Published: England 01.06.1993
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Brain - metabolism; Cell Transformation, Neoplastic; Chromosome Banding; Chromosome Mapping; Chromosomes, Human, Pair 12; Cloning, Molecular; Cyclin D2; Cyclins - genetics; DNA, Neoplasm - genetics; DNA, Neoplasm - isolation & purification; Exons; Gene Library; Humans; Leukemia, T-Cell - genetics; Mice; Molecular Sequence Data; Multigene Family; Mutagenesis, Insertional; Oncogenes; Proviruses - genetics; Rats; Restriction Mapping; Sequence Homology, Amino Acid; Spleen - metabolism; Transcription, Genetic; Virus Integration
• ISSN: 0950-9232

The Vin-1 gene was initially identified as a gene whose expression is altered by the integration of proviruses in the Vin-1 common site of integration in retrovirus-induced rodent T-cell leukemias. We have now isolated the Vin-1 cDNA. Sequencing of the Vin-1 cDNA and Vin-1 exons revealed that the proviruses are integrated at the 5' end of the Vin-1 gene in an inverse transcriptional orientation. The sequence of the Vin-1 gene is identical to that of the recently identified G1-phase cyclin D2 gene. The human homolog of the Vin-1/cyclin D2 gene (CCND2) was mapped to chromosome 12, band p13.3, by in situ hybridization, confirming previous mapping data. Our results strongly support a role of the cyclin D2 gene in oncogenesis and thereby implicate altered cell cycle regulation in transformation.