Lipid peroxidation in human breast cancer cells in response to gamma-linolenic acid and iron

Lipid peroxidation in human breast cancer (ZR-75-1) cells and cancer cell killing were confirmed by using ultraviolet (UV)-spectrophotometry and mass spectrometry (MS). ZR-75-1 cells and human normal fibroblast CCD-41-SK (41Sk) cells were cultured with gamma-linolenic acid (GLA) and ferrous iron Fe...

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Bibliographic Details
Published inAnticancer research Vol. 12; no. 2; p. 329
Main Authors Takeda, S, Horrobin, D F, Manku, M, Sim, P G, Ells, G, Simmons, V
Format Journal Article
LanguageEnglish
Published Greece 01.03.1992
Subjects
Antineoplastic Agents - pharmacology
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cell Survival - drug effects
Female
gamma-Linolenic Acid
Humans
Iron - pharmacology
Linolenic Acids - pharmacology
Lipid Peroxidation - drug effects
Tumor Cells, Cultured
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Summary:Lipid peroxidation in human breast cancer (ZR-75-1) cells and cancer cell killing were confirmed by using ultraviolet (UV)-spectrophotometry and mass spectrometry (MS). ZR-75-1 cells and human normal fibroblast CCD-41-SK (41Sk) cells were cultured with gamma-linolenic acid (GLA) and ferrous iron Fe (II) combinations. Formation of lipid peroxide and cytotoxic effect were highest in ZR-75-1 cells treated with GLA + Fe (II), though 41Sk cells showed little evidence of either lipid peroxidation or cytotoxity. These results indicate a cancer-cell-specific lipid peroxidation mechanism in association with the selective cancer cell killing effect in response to GLA.
ISSN:0250-7005
1791-7530