A multivariate analysis of en bloc extended radical mastectomy versus conventional radical mastectomy in operable breast cancer

• Published in: International surgery Vol. 77; no. 1; p. 48
• Main Authors: Noguchi, M, Taniya, T, Koyasaki, N, Miyazaki, I
• Format: Journal Article
• Language: English
• Published: Italy 01.01.1992
• Subjects: Aged; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Humans; Lymphatic Metastasis; Male; Mastectomy, Extended Radical; Mastectomy, Radical; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local - mortality; Survival Rate; Time Factors
• ISSN: 0020-8868

We made clinical trials of en bloc extended radical mastectomy (EXT) of a new type in 118 patients from 1980 through 1985. A variety of conventional radical mastectomies (RDL) were also performed in 105 patients from 1973 through 1985. A multivariate analysis was performed of the results to compare EXT and RDL. The result showed the 5-year survival rates of 91 +/- 2.6% and 83 +/- 3.7% were achieved for the EXT and RDL groups, respectively (Cox P value for comparison of survival curves = 0.16). Adjusted Cox regression analysis revealed a significantly favourable result of EXT (P = 0.05). This difference was most remarkable in patients with one to three metastatic axillary lymph nodes, although it was not statistically significant because of too small a number of patients available (P = 0.18). The results are thus not definite, but suggest that EXT may be advantageous over RDL especially in patients with a few metastatic axillary lymph nodes.