A multivariate analysis of en bloc extended radical mastectomy versus conventional radical mastectomy in operable breast cancer

We made clinical trials of en bloc extended radical mastectomy (EXT) of a new type in 118 patients from 1980 through 1985. A variety of conventional radical mastectomies (RDL) were also performed in 105 patients from 1973 through 1985. A multivariate analysis was performed of the results to compare...

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Bibliographic Details
Published inInternational surgery Vol. 77; no. 1; p. 48
Main Authors Noguchi, M, Taniya, T, Koyasaki, N, Miyazaki, I
Format Journal Article
LanguageEnglish
Published Italy 01.01.1992
Subjects
Aged
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Humans
Lymphatic Metastasis
Male
Mastectomy, Extended Radical
Mastectomy, Radical
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local - mortality
Survival Rate
Time Factors
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Summary:We made clinical trials of en bloc extended radical mastectomy (EXT) of a new type in 118 patients from 1980 through 1985. A variety of conventional radical mastectomies (RDL) were also performed in 105 patients from 1973 through 1985. A multivariate analysis was performed of the results to compare EXT and RDL. The result showed the 5-year survival rates of 91 +/- 2.6% and 83 +/- 3.7% were achieved for the EXT and RDL groups, respectively (Cox P value for comparison of survival curves = 0.16). Adjusted Cox regression analysis revealed a significantly favourable result of EXT (P = 0.05). This difference was most remarkable in patients with one to three metastatic axillary lymph nodes, although it was not statistically significant because of too small a number of patients available (P = 0.18). The results are thus not definite, but suggest that EXT may be advantageous over RDL especially in patients with a few metastatic axillary lymph nodes.
ISSN:0020-8868