Synthesis and antiparasitic activities of amidinic azolated derivatives

A set of heterocyclic N-acetamidinium hydrochlorides were prepared from the corresponding N-acetonitriles. The antiparasitic screening showed that, while all amidines are practically inactive, some nitriles present leishmanicide properties.

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Bibliographic Details
Published inFarmaco (Società chimica italiana : 1989) Vol. 52; no. 4; pp. 227 - 229
Main Authors Danan, A, Charon, D, Kirkiacharian, S, Bories, C, Loiseau, PM
Format Journal Article
LanguageEnglish
Published LAUSANNE Elsevier 01.04.1997
Subjects
Acetonitriles - chemical synthesis
Acetonitriles - pharmacology
Amidines - chemical synthesis
Amidines - chemistry
Amidines - pharmacology
Animals
Antiprotozoal Agents - chemical synthesis
Antiprotozoal Agents - pharmacology
Leishmania donovani - drug effects
Leishmania major - drug effects
Life Sciences & Biomedicine
Molecular Structure
Pharmacology & Pharmacy
Rhabditoidea - drug effects
Science & Technology
Trichomonas vaginalis - drug effects
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Summary:A set of heterocyclic N-acetamidinium hydrochlorides were prepared from the corresponding N-acetonitriles. The antiparasitic screening showed that, while all amidines are practically inactive, some nitriles present leishmanicide properties.
ISSN:0014-827X