Metabolic problems in northeastern Thailand: possible role of vanadium

Common metabolic problems in northeastern Thailand include renal stone disease, distal renal tubular acidosis, hypokalemic periodic paralysis, sudden unexplained nocturnal death and malnutrition-related diabetes mellitus. There is evidence of decreased activity of Na,K-ATPase and H,K-ATPase. A preli...

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Published inMineral and electrolyte metabolism Vol. 19; no. 1; p. 51
Main Authors Sitprija, V, Tungsanga, K, Tosukhowong, P, Leelhaphunt, N, Kruerklai, D, Sriboonlue, P, Saew, O
Format Journal Article
LanguageEnglish
Published Switzerland 1993
Subjects
Humans
Kidney - chemistry
Liver - chemistry
Lung - chemistry
Proton Pump Inhibitors
Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors
Soil - analysis
Thailand
Vanadium - analysis
Vanadium - poisoning
Vanadium - urine
Water - analysis
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Summary:Common metabolic problems in northeastern Thailand include renal stone disease, distal renal tubular acidosis, hypokalemic periodic paralysis, sudden unexplained nocturnal death and malnutrition-related diabetes mellitus. There is evidence of decreased activity of Na,K-ATPase and H,K-ATPase. A preliminary study was made of the vanadium concentration in the soil and water in northeastern Thailand. The urinary and tissue vanadium concentrations were also determined in the northeastern villagers. The soil was found to have high vanadium content. The vanadium content was also high in the urine, kidneys and lungs of the villagers. It is postulated that these metabolic problems are attributed to the inhibition of Na,K-ATPase and H,K-ATPase activity by vanadium.
ISSN:0378-0392