Static and flow cytometric DNA analysis compared to histologic prognostic factors in a cohort of stage T2 breast cancer

DNA analysis with static and flow cytometry was performed on archival smears and tissue sections in 99 patients with T2 breast cancer (Stage II). Tumour size, histologic grade and axillary node metastases were significant prognostic predictors. Static cytometry revealed 63% aneuploid tumours, and pl...

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Bibliographic Details
Published inEuropean journal of surgical oncology Vol. 16; no. 3; p. 200
Main Authors Arnerlöv, C, Emdin, S O, Roos, G, Angström, T, Bjersing, L, Angquist, K A, Jonsson, H
Format Journal Article
LanguageEnglish
Published England 01.06.1990
Subjects
Adenocarcinoma - genetics
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adenocarcinoma - secondary
Breast Neoplasms - genetics
Breast Neoplasms - mortality
Breast Neoplasms - pathology
DNA, Neoplasm - analysis
Female
Flow Cytometry
Follow-Up Studies
Humans
Lymphatic Metastasis
Multivariate Analysis
Neoplasm Staging
Ploidies
Prognosis
Survival Analysis
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Summary:DNA analysis with static and flow cytometry was performed on archival smears and tissue sections in 99 patients with T2 breast cancer (Stage II). Tumour size, histologic grade and axillary node metastases were significant prognostic predictors. Static cytometry revealed 63% aneuploid tumours, and ploidy was significantly correlated to histologic grade and survival. DNA measurements obtained by static and flow cytometry were strongly correlated. According to flow cytometry 53% of the tumours were aneuploid. Flow cytometric DNA analysis correlated to histologic grade and survival and gave prognostic information among the lymph-node negative patients. Ploidy seems to be a significant, although not an independent prognostic indicator for T2 breast cancer.
ISSN:0748-7983