Antitussive effects of levodropropizine in the dog

The antitussive activity of levodropropizine (S(-)3-(4-phenyl-piperazine-1-yl)-propane-1,2-diol, DF 526, CAS 99291-25-5) was evaluated after oral administration to the conscious dog. Levodropropizine had a good antitussive activity, comparable with, but having a longer duration of action than dropro...

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Bibliographic Details
Published inArzneimittel-Forschung Vol. 44; no. 2; p. 153
Main Authors Munt, P L, Clavenna, G, Algate, D R, Leach, R M
Format Journal Article
LanguageEnglish
Published Germany 01.02.1994
Subjects
Animals
Antitussive Agents - pharmacology
Codeine - pharmacology
Cough - drug therapy
Dogs
Dose-Response Relationship, Drug
Electric Stimulation
Female
Male
Propylene Glycols - pharmacology
Stereoisomerism
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Summary:The antitussive activity of levodropropizine (S(-)3-(4-phenyl-piperazine-1-yl)-propane-1,2-diol, DF 526, CAS 99291-25-5) was evaluated after oral administration to the conscious dog. Levodropropizine had a good antitussive activity, comparable with, but having a longer duration of action than dropropizine, the racemate from which it is derived. The antitussive activity of levodropropizine in the dog was approximately 1/20 of that of codeine phosphate.
ISSN:0004-4172