Synthesis of thiazole derivatives with positive inotropic effect

Thiazole derivatives with potential positive inotropic effect were synthesized. The highest activity (medium positive inotropic effect) was exhibited by ethyl 2-(2-hydroxyethylamino)-4-phenylthiazole-5-carboxylate (3b) of which several derivatives have been prepared. Among these derivatives only tho...

Full description

Saved in:
Bibliographic Details
Published inPharmazie Vol. 42; no. 6; p. 373
Main Authors Kosáry, J, Kasztreiner, E, Rablóczky, G, Vitális, B
Format Journal Article
LanguageEnglish
Published Germany 01.06.1987
Subjects
Animals
Cardiotonic Agents - chemical synthesis
Cats
Chemical Phenomena
Chemistry
Heart Rate - drug effects
Propranolol - pharmacology
Thiazoles - chemical synthesis
Thiazoles - pharmacology
Online AccessGet more information

Cover

More Information
Summary:Thiazole derivatives with potential positive inotropic effect were synthesized. The highest activity (medium positive inotropic effect) was exhibited by ethyl 2-(2-hydroxyethylamino)-4-phenylthiazole-5-carboxylate (3b) of which several derivatives have been prepared. Among these derivatives only those which could presumably easily removed in the living organism to give 3b exhibited a medium positive inotropic effect (6, 8b). It was assumed that the effect of 3b had a beta-agonist character.
ISSN:0031-7144