Pathogenesis and pharmacologic management of pseudo-obstruction of the bowel in pheochromocytoma

Metastatic malignant pheochromocytoma can be a disease of long duration and though poorly responsive to both radiation therapy and chemotherapy, pharmacologic management of its myriad manifestations can be very effective. Hypertension is the most recognized feature of this disease, but gastrointesti...

Full description

Saved in:
Bibliographic Details
Published inThe American journal of the medical sciences Vol. 290; no. 4; p. 155
Main Authors Mullen, J P, Cartwright, R C, Tisherman, S E, Misage, J R, Shapiro, A P
Format Journal Article
LanguageEnglish
Published United States 01.10.1985
Subjects
Adrenal Gland Neoplasms - metabolism
Adrenergic alpha-Antagonists - therapeutic use
Adrenergic beta-Antagonists - therapeutic use
Adult
Catecholamines - metabolism
Constipation - drug therapy
Constipation - etiology
Fecal Impaction - etiology
Female
Humans
Intestinal Obstruction - etiology
Intestinal Pseudo-Obstruction - drug therapy
Intestinal Pseudo-Obstruction - etiology
Male
Pheochromocytoma - complications
Pheochromocytoma - metabolism
Pheochromocytoma - secondary
Online AccessGet more information

Cover

More Information
Summary:Metastatic malignant pheochromocytoma can be a disease of long duration and though poorly responsive to both radiation therapy and chemotherapy, pharmacologic management of its myriad manifestations can be very effective. Hypertension is the most recognized feature of this disease, but gastrointestinal manifestations can, on rare occasions, be just as serious and life threatening. We present two patients with metastatic pheochromocytoma who developed pseudo-obstruction, and discuss the pathopharmacology and treatment of this syndrome.
ISSN:0002-9629
DOI:10.1097/00000441-198510000-00004