Electron microscopy of psoriatic skin before and after psoralen/ultraviolet A treatment

Skin biopsy specimens of patients with psoriasis receiving psoralen/ultraviolet A treatment were examined. A decrease in tonofilaments and keratohyaline granules and enlarged intercellular spaces were common findings in all cases. Hyperchromatic nuclei in the horny cells and hyperactive keratinocyte...

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Bibliographic Details
Published inCutis (New York, N.Y.) Vol. 58; no. 1; p. 83
Main Authors Mete, U O, Denli, Y G, Ozbilgin, M K, Tap, O, Acar, M A, Kaya, M, Memisoglu, H R
Format Journal Article
LanguageEnglish
Published United States 01.07.1996
Subjects
Adult
Biopsy, Needle
Female
Humans
Male
Microscopy, Electron
Middle Aged
Psoriasis - drug therapy
Psoriasis - pathology
PUVA Therapy
Skin - ultrastructure
Treatment Outcome
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Summary:Skin biopsy specimens of patients with psoriasis receiving psoralen/ultraviolet A treatment were examined. A decrease in tonofilaments and keratohyaline granules and enlarged intercellular spaces were common findings in all cases. Hyperchromatic nuclei in the horny cells and hyperactive keratinocytes in the malpighian layer were also observed. Treatment resulted in normalization of keratinocytes and stimulation of melanocytes. Our study revealed that psoralen/ultraviolet A is effective and important in the treatment of psoriasis, but patients should be evaluated for atypical changes.
ISSN:0011-4162