Intravenous remifentanil : Placental transfer, maternal and neonatal effects

• Published in: Anesthesiology (Philadelphia) Vol. 88; no. 6; pp. 1467 - 1474
• Main Authors: KAN, R. E, HUGHES, S. C, ROSEN, M. A, KESSIN, C, PRESTON, P. G, LOBO, E. P
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01.06.1998
• Subjects: Adolescent; Adult; Analgesics; Anesthesia, Obstetrical; Anesthetics, Intravenous - pharmacokinetics; Apgar Score; Biological and medical sciences; Blood Gas Analysis; Cesarean Section; Double-Blind Method; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Medical sciences; Neuropharmacology; Pharmacology. Drug treatments; Piperidines - pharmacokinetics; Pregnancy; Remifentanil; Human; Intravenous administration; Toxicity; Placental transfer; Opiates; Narcotic analgesic; Obstetrics; Remifentanil; Analgesia; Regional anesthesia; Mother; Surgery; Female; Fetus; Pharmacokinetics; Cesarean section
• ISSN: 0003-3022; 1528-1175
• DOI: 10.1097/00000542-199806000-00008

Remifentanil has not been studied in obstetric patients. This study evaluates the placental transfer of remifentanil and the neonatal effects when administered as an intravenous infusion. Nineteen parturients underwent nonemergent cesarean section with epidural anesthesia and received 0.1 microg kg(-1) x min(-1) remifentanil intravenously, which was continued until skin closure. Maternal arterial (MA), umbilical arterial (UA), and umbilical venous (UV) blood samples were obtained at delivery for analysis of drug concentrations of remifentanil, its metabolite, and blood gases. Maternal vital signs were monitored continuously, and pain and sedation levels were assessed intermittently. Apgar scores were obtained at 1, 5, 10, and 20 min, and Neonatal and Adaptive Capacity Scores were noted 30 and 60 min after delivery. Parturients and newborns were observed for at least 24 h after surgery for side effects. The means and SDs of UV:MA and UA:UV ratios for remifentanil were 0.88+/-0.78 and 0.29+/-0.07, respectively. Mean clearance was 93 ml x min(-1) kg(-1). The mean UV:MA and UA:MV ratios for remifentanil acid were 0.56+/-0.29 and 1.23+/-0.89, respectively. The mean MA (remifentanil acid):MA (remifentanil) ratio was 2.92+/-3.65. There were no adverse effects on the neonates, but there was a sedative effect and respiratory depressant effect on the mothers. Remifentanil crosses the placenta but appears to be rapidly metabolized, redistributed, or both. Maternal sedation and respiratory changes occur, but without adverse neonatal or maternal effects.