Colorectal cancer after pelvic irradiation: case reports

Four patients with colorectal cancer after pelvic irradiation for gynaecological malignancies are reported. The interval between irradiation and the diagnosis of colorectal cancer was 15-28 years. Histological findings of radiation proctocolitis adjacent to the cancer were observed in all specimens....

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Bibliographic Details
Published inAnticancer research Vol. 17; no. 1B; p. 729
Main Authors Tsunoda, A, Shibusawa, M, Kawamura, M, Marumori, T, Kusano, M, Ohta, H
Format Journal Article
LanguageEnglish
Published Greece 01.01.1997
Subjects
Adenocarcinoma, Mucinous - pathology
Adult
Aged
Fatal Outcome
Female
Humans
Intestinal Polyps - pathology
Middle Aged
Neoplasms, Radiation-Induced - pathology
Neoplasms, Second Primary - pathology
Ovarian Neoplasms - radiotherapy
Rectal Neoplasms - pathology
Sigmoid Neoplasms - pathology
Uterine Cervical Neoplasms - radiotherapy
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Summary:Four patients with colorectal cancer after pelvic irradiation for gynaecological malignancies are reported. The interval between irradiation and the diagnosis of colorectal cancer was 15-28 years. Histological findings of radiation proctocolitis adjacent to the cancer were observed in all specimens. Ki-67 immunohistologic staining showed high cell proliferation activity in the irradiated mucosa of a recently removed specimen. Although irradiation has not been proved to induce colorectal cancer, considerable circumstantial evidence supports this belief. Awareness of this potential long-term complication is important when planing the follow-up of patients subjected to pelvic radiotherapy.
ISSN:0250-7005