Prevention of preatheromatous lesions in sand rats by treatment with a nutritional supplement

Sand rats fed a hypercholesterolaemic diet containing 0.01% of the anti-thyroid agent 2-mercapto-1-imidazole develop preatheromatous lesions similar to those found in humans, in addition to obesity and insulin resistance. The effects of a nutritional supplement rich in essential fatty acids and garl...

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Bibliographic Details
Published inArzneimittel-Forschung Vol. 46; no. 6; p. 610
Main Authors Marquié, G, Menouar, T, Pieraggi, M T, Dousset, N, Bennani, N
Format Journal Article
LanguageEnglish
Published Germany 01.06.1996
Subjects
Animal Nutritional Physiological Phenomena
Animals
Arteriosclerosis - prevention & control
Blood Glucose - metabolism
Cholesterol, LDL - metabolism
Diet
Gerbillinae - physiology
Half-Life
Hormones - blood
Insulin - blood
Male
Triglycerides - metabolism
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Summary:Sand rats fed a hypercholesterolaemic diet containing 0.01% of the anti-thyroid agent 2-mercapto-1-imidazole develop preatheromatous lesions similar to those found in humans, in addition to obesity and insulin resistance. The effects of a nutritional supplement rich in essential fatty acids and garlic extract (Arterodiet) on the appearance and evolution of the lesions were studied. Treatment with this nutritional supplement significantly decreased circulating triglycerides and low-density lipoprotein (LDL)-cholesterol levels but did not alter plasma insulin or glucose levels. Intra-arterial cholesterol levels were also decreased by the treatment which resulted in a normalisation of the atherosclerotic lesions in these animals.
ISSN:0004-4172