The pharmacokinetic profile of naproxen suppository in man

After a rectal dose of 500 mg in a suppository, naproxen is 6-O-demethylated (20%) and glucuronidated (40%), the metabolites are subsequently excreted renally. The elimination half-life is 15.2 +/- 2.6 h. Ten out of 22 subjects show biphasic elimination kinetics with half-lives of 7 and 15 h, respec...

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Bibliographic Details
Published inInternational journal of clinical pharmacology, therapy, and toxicology Vol. 26; no. 4; p. 190
Main Authors Guelen, P J, Janssen, T J, Brueren, M M, Vree, T B, Lipperts, G J
Format Journal Article
LanguageEnglish
Published Germany 01.04.1988
Subjects
Adult
Chromatography, High Pressure Liquid
Female
Half-Life
Humans
Male
Naproxen - administration & dosage
Naproxen - analogs & derivatives
Naproxen - blood
Naproxen - pharmacokinetics
Suppositories
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Summary:After a rectal dose of 500 mg in a suppository, naproxen is 6-O-demethylated (20%) and glucuronidated (40%), the metabolites are subsequently excreted renally. The elimination half-life is 15.2 +/- 2.6 h. Ten out of 22 subjects show biphasic elimination kinetics with half-lives of 7 and 15 h, respectively. There is a wide range in the percentage of the dose that is glucuronidated and demethylated (20-70%). This variation does not deviate from a normal distribution.
ISSN:0174-4879