Effect of mifegin on the content of cyclic nucleotides in the cervical myometrium in full-term pregnancy

Cervical myometrium was examined in 22 pregnant women at 39-41 weeks gestation at risk of labor abnormalities. The patients received mifegin for preparing to labor. A new component in the mechanism of mifegin effect on the uterine cervix in full-term pregnancy was revealed: mifegin elevated the cont...

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 134; no. 4; pp. 349 - 350
Main Authors Sergeev, P V, Kareva, E N, Gasparyan, N D, Podval'nyuk, V V
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.10.2002
Subjects
Administration, Oral
Adult
Cyclic AMP - metabolism
Cyclic GMP - metabolism
Drug Administration Schedule
Female
Humans
Labor, Obstetric - metabolism
Mifepristone - administration & dosage
Mifepristone - pharmacology
Myometrium - drug effects
Myometrium - metabolism
Pregnancy - metabolism
Pregnancy Outcome
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Summary:Cervical myometrium was examined in 22 pregnant women at 39-41 weeks gestation at risk of labor abnormalities. The patients received mifegin for preparing to labor. A new component in the mechanism of mifegin effect on the uterine cervix in full-term pregnancy was revealed: mifegin elevated the content of cAMP by 50% and almost 2-fold increased the cAMP/cGMP ratio compared to the initial level.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1021900129419