Managing issues related to antiretroviral therapy

Antiretroviral regimens are complicated and difficult for patients to follow, and they can have serious side effects, such as osteonecrosis and bone demineralization. Protease inhibitor therapy has been associated with hyperlipidemia, hyperglycemia, gastrointestinal symptoms, and body-fat distributi...

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Bibliographic Details
Published inAmerican family physician Vol. 68; no. 4; p. 675
Main Authors Lesho, Emil P, Gey, Daniela C
Format Journal Article
LanguageEnglish
Published United States American Academy of Family Physicians 15.08.2003
Subjects
Anti-HIV Agents - adverse effects
Anti-HIV Agents - therapeutic use
Antiretroviral Therapy, Highly Active - adverse effects
Bone Diseases - chemically induced
Drug Interactions
Drug therapy
Gastrointestinal Diseases - chemically induced
HIV
HIV Infections - drug therapy
HIV Protease Inhibitors - adverse effects
HIV Protease Inhibitors - therapeutic use
Human immunodeficiency virus
Humans
Infections
Patient Compliance
Pharmacology
Prescription drugs
Reverse Transcriptase Inhibitors - adverse effects
Reverse Transcriptase Inhibitors - therapeutic use
Side effects
Skin Diseases - chemically induced
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Summary:Antiretroviral regimens are complicated and difficult for patients to follow, and they can have serious side effects, such as osteonecrosis and bone demineralization. Protease inhibitor therapy has been associated with hyperlipidemia, hyperglycemia, gastrointestinal symptoms, and body-fat distribution abnormalities. Nonnucleoside reverse transcriptase inhibitors can cause rashes and hepatotoxicity, and nucleoside reverse transcriptase inhibitors can cause lactic acidosis, hypersensitivity reactions, neuropathies, pancreatitis, anemia, and neutropenia. Malabsorption can occur if antiretroviral agents are taken improperly with regard to meals or if they are taken with certain other drugs or herbal remedies. Some commonly prescribed drugs can cause dangerous drug toxicities if they are taken by patients who are also taking certain antiretroviral medications. Suboptimal exposure to antiretrovirals because of noncompliance or malabsorption can result in viral resistance and loss of future treatment options.
ISSN:0002-838X