Age-specific ultrastructural postradiation changes in intestinal endocrine cells

Age-specific ultrastructural postradiation changes in the main types of duodenal endocrine cells (apudocytes) were studied in rats 6 and 12 months after single whole-body irradiation in doses of 7 and 7.5 Gy. Ultrastructural disorganization of different severity was detected, which depended on apudo...

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 132; no. 5; p. 1110
Main Authors Odintsova, E A, Kvetnoi, I M, Trofimov, A V, Popuchiev, V V, Yakovleva, N D
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.11.2001
Subjects
Age Factors
Animals
Dose-Response Relationship, Radiation
Duodenum - pathology
Endocrine Glands - cytology
Endocrine Glands - drug effects
Endocrine Glands - ultrastructure
Intestines - cytology
Male
Microscopy, Electron
Mitochondria - pathology
Rats
Rats, Wistar
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Summary:Age-specific ultrastructural postradiation changes in the main types of duodenal endocrine cells (apudocytes) were studied in rats 6 and 12 months after single whole-body irradiation in doses of 7 and 7.5 Gy. Ultrastructural disorganization of different severity was detected, which depended on apudocyte type and term postradiation. Degranulation was the basic mechanism of hormone secretion in delayed periods after the exposure.
ISSN:0007-4888
1573-8221