Pathomorphological and immunohistochemical analysis biopsy specimens from large bronchi of patients with pulmonary cancer

Biopsy specimens from large bronchi of patients with central and peripheral pulmonary cancer were studied. Central cancer was associated with hyperplasia and dysplasia of the epithelium, hyperplasia of glandular compartment, and pronounced immunocompetent cell response. Peripheral cancer was charact...

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Published inBulletin of experimental biology and medicine Vol. 134; no. 2; pp. 198 - 202
Main Authors Nepomnyashchikh, G I, Levitskii, V A, Dolgovykh, A K, Naumova, L A
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.08.2002
Subjects
Adult
Aged
Biopsy
Bronchi - pathology
Female
Humans
Immunohistochemistry
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Male
Microscopy, Electron
Middle Aged
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Summary:Biopsy specimens from large bronchi of patients with central and peripheral pulmonary cancer were studied. Central cancer was associated with hyperplasia and dysplasia of the epithelium, hyperplasia of glandular compartment, and pronounced immunocompetent cell response. Peripheral cancer was characterized by predominance of atrophic and sclerotic changes, lymph flow disorders, and tendency to lymphoid aggregation. These data suggest that not only dysplasia, but also the combination of all structural changes typical of each form of pulmonary cancer should be considered as a morphological marker of enhanced risk of tumor development.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1023/A:1021108920079