E2F-1 induced apoptosis

Members of the E2F family of transcription factors play an important role in regulating the cell cycle, and their activity is often perturbed during the development of human malignancies. More recent work has shown that E2F-1 regulates apoptosis as well as proliferation, in part by stabilizing the p...

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Bibliographic Details
Published inApoptosis (London) Vol. 6; no. 3; pp. 173 - 182
Main Authors Phillips, A C, Vousden, K H
Format Journal Article
LanguageEnglish
Published Netherlands Springer Nature B.V 01.06.2001
Subjects
Animals
Apoptosis
Cell Cycle
Cell Cycle Proteins
DNA-Binding Proteins - genetics
E2F Transcription Factors
E2F1 Transcription Factor
Genes, p53 - genetics
Genes, Tumor Suppressor
Humans
Models, Biological
Nuclear Proteins - genetics
Proteins
Signal Transduction
Transcription Factors - metabolism
Transcription, Genetic
Tumor Protein p73
Tumor Suppressor Proteins
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Summary:Members of the E2F family of transcription factors play an important role in regulating the cell cycle, and their activity is often perturbed during the development of human malignancies. More recent work has shown that E2F-1 regulates apoptosis as well as proliferation, in part by stabilizing the p53 tumor suppressor, an important mediator of apoptosis. This has led to the suggestion that E2F-1 may function as a tumor surveillance mechanism, detecting aberrant proliferation and engaging apoptotic pathways to protect the organism from developing tumors.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1360-8185
1573-675X
DOI:10.1023/A:1011332625740