Atrial fibrillation: defining potential curative ablation targets

• Published in: Journal of interventional cardiac electrophysiology Vol. 4 Suppl 1; no. 1; pp. 141 - 147
• Main Authors: Benditt, D G, Samniah, N, Fahy, G J, Lurie, K G, Sakaguchi, S
• Format: Journal Article
• Language: English
• Published: Netherlands Springer Nature B.V 01.01.2000
• Subjects: Atrial Fibrillation - diagnosis; Atrial Fibrillation - mortality; Atrial Fibrillation - surgery; Catheter Ablation - methods; Catheter Ablation - mortality; Clinical Trials as Topic; Female; Follow-Up Studies; Humans; Male; Survival Rate; Treatment Outcome
• ISSN: 1383-875X; 1572-8595
• DOI: 10.1023/A:1009807304917

The concept that atrial fibrillation (or at least certain forms of the arrhythmia) may be amenable to reversal or amelioration by transcatheter ablation techniques has become increasingly accepted in recent years. As yet, however, the techniques being studied for ablation of atrial fibrillation address neither known critical anatomic elements nor well defined electrophysiologic markers. The approaches, although essentially empirical, are conceptually based on the 'multiple wavelet' or 'focal origin' hypotheses. To date, addressing 'focal origin' atrial fibrillation by transcatheter ablation has been the more encouraging. However, as technology evolves, both in terms of catheter design and possibly endocardial mapping techniques, approaches to wavelet or rotor mechanisms may become similarly effective. This communication examines concepts regarding the manner in which atrial fibrillation is initiated and maintained. The goals are to better understand the encouraging success of empirical ablation methods, and possibly derive insights which may help refine ablation targeting in the future.