Treatment of pure red cell aplasia associated with multiple myeloma with biclonal gammopathy using cyclosporine A: a case report

We reported a rare case of pure red cell aplasia in a 44-year-old man with multiple myeloma with biclonal gammophathy (IgG lambda and IgA lambda type) with severe anemia. After treatment with bortezomib, adriamycin, and dexamethasone, the patient achieved very good partial response with disappearanc...

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Bibliographic Details
Published inInternational journal of clinical and experimental medicine Vol. 8; no. 1; pp. 1498 - 1500
Main Authors Lv, Yali, Qian, Wenbin
Format Journal Article
LanguageEnglish
Published United States e-Century Publishing Corporation 01.01.2015
Subjects
Case Report
cyclosporine A
bortezomib
pure red cell aplasia
Multiple myeloma
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Summary:We reported a rare case of pure red cell aplasia in a 44-year-old man with multiple myeloma with biclonal gammophathy (IgG lambda and IgA lambda type) with severe anemia. After treatment with bortezomib, adriamycin, and dexamethasone, the patient achieved very good partial response with disappearance of monoclonal gammopathy. However, his anemia was not significantly improved. Bone marrow analysis revealed selective erythroid hypoplasia. Thus, cyclosporine A was administered, which resulted in a complete recovery from anemia. The present case may provide some insight into the pathogenesis of PRAC and malignant plasma cell disorder.
ISSN:1940-5901
1940-5901