Selenium‐Based Catalytic Scavengers for Concurrent Scavenging of H2S and Reactive Oxygen Species
Hydrogen sulfide (H2S) is an endogenous gasotransmitter that plays important roles in redox signaling. H2S overproduction has been linked to a variety of disease states and therefore, H2S‐depleting agents, such as scavengers, are needed to understand the significance of H2S‐based therapy. It is know...
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Published in | Angewandte Chemie International Edition Vol. 63; no. 6 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
Wiley Subscription Services, Inc
05.02.2024
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Edition | International ed. in English |
Subjects | |
Online Access | Get full text |
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Summary: | Hydrogen sulfide (H2S) is an endogenous gasotransmitter that plays important roles in redox signaling. H2S overproduction has been linked to a variety of disease states and therefore, H2S‐depleting agents, such as scavengers, are needed to understand the significance of H2S‐based therapy. It is known that elevated H2S can induce oxidative stress with elevated reactive oxygen species (ROS) formation, such as in H2S acute intoxication. We explored the possibility of developing catalytic scavengers to simultaneously remove H2S and ROS. Herein, we studied a series of selenium‐based molecules as catalytic H2S/H2O2 scavengers. Inspired by the high reactivity of selenoxide compounds towards H2S, 14 diselenide/monoselenide compounds were tested. Several promising candidates such as S6 were identified. Their activities in buffers, as well as in plasma‐ and cell lysate‐containing solutions were evaluated. We also studied the reaction mechanism of this scavenging process. Finally, the combination of the diselenide catalyst and photosensitizers was used to achieve light‐induced H2S removal. These Se‐based scavengers can be useful tools for understanding H2S/ROS regulations.
H2S overproduction is linked to various disease states while chemical tools that can precisely downregulate H2S are still lacking. In this work, selenoxide‐containing compounds were found to be potent H2S scavengers with promising antidotal effects for H2S poisoning. Several diselenides were further developed as catalytic scavengers for both H2S and H2O2. |
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ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.202317487 |