Angiogenesis assays: problems and pitfalls

Many studies of angiogenesis inducers and inhibitors rely on in vitro or in vivo models as indicators of efficacy. However, as valuable as these models are, there are limitations to each one of these. This overview describes some of the principal methods now in use and discusses the advantages and s...

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Bibliographic Details
Published inCancer and metastasis reviews Vol. 19; no. 1-2; p. 167
Main Authors Auerbach, R, Akhtar, N, Lewis, R L, Shinners, B L
Format Journal Article
LanguageEnglish
Published Netherlands Springer Nature B.V 2000
Subjects
Angiogenesis
Angiogenesis Inhibitors - pharmacology
Animals
Biological Assay - methods
Cancer
Cells, Cultured
Chick Embryo
Humans
Neovascularization, Pathologic - physiopathology
Neovascularization, Pathologic - prevention & control
Neovascularization, Physiologic - drug effects
Neovascularization, Physiologic - physiology
Organ Culture Techniques
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Summary:Many studies of angiogenesis inducers and inhibitors rely on in vitro or in vivo models as indicators of efficacy. However, as valuable as these models are, there are limitations to each one of these. This overview describes some of the principal methods now in use and discusses the advantages and some of the limitations of these methods. It is suggested that multiple assays, involving both in vitro and in vivo assays, are at present the best way to minimize the problems inherent in any specific assay.
ISSN:0167-7659
1573-7233
DOI:10.1023/A:1026574416001