Unstable familial translocations: A t(11;22)mat inherited as a t(11;15)

Unusual inheritance of a reciprocal translocation, t(11;22)(p11;p12)mat was discovered in a family with one daughter having a different translocation, t(11;15)(p11;p12). Another daughter inherited the same translocation as her mother. The breakpoints through the nucleolar organizing regions (NORs) o...

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Bibliographic Details
Published inAmerican journal of human genetics Vol. 33; no. 5; pp. 745 - 751
Main Author Tomkins, D J
Format Journal Article
LanguageEnglish
Published United States 01.09.1981
Subjects
Abortion, Habitual - genetics
Chromosomes, Human, 13-15
Chromosomes, Human, 21-22 and Y
Chromosomes, Human, 6-12 and X
Female
Humans
Karyotyping
Male
Phenotype
Pregnancy
Translocation, Genetic
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Summary:Unusual inheritance of a reciprocal translocation, t(11;22)(p11;p12)mat was discovered in a family with one daughter having a different translocation, t(11;15)(p11;p12). Another daughter inherited the same translocation as her mother. The breakpoints through the nucleolar organizing regions (NORs) of chromosomes 15 and 22 were determined by silver staining. A review of the literature has demonstrated that such unstable familial translocations are very rare and can occur either in mitosis or meiosis. They usually involve exchanges between centromeres, telomeres, or NORs.
ISSN:0002-9297
1537-6605