Sustainable and biocompatible hybrid materials-based sulfated polysaccharides for biomedical applications: a review
Sustainable biomaterials that are both efficient and environmentally friendly are the subject of research and development efforts among scientists and academics from a variety of contemporary scientific disciplines. Due to their significant involvement in several physiological and pathological proce...
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| Published in | RSC advances Vol. 15; no. 6; pp. 478 - 4767 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
06.02.2025
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Sustainable biomaterials that are both efficient and environmentally friendly are the subject of research and development efforts among scientists and academics from a variety of contemporary scientific disciplines. Due to their significant involvement in several physiological and pathological processes, sulfated polysaccharides (SPs) have garnered growing interest across various application domains, including biomedicine. Nevertheless, mechanical and thermal stability are issues for unmodified polysaccharide materials. Interactions between polymers, such as the mixing of biopolymers with synthetic or biopolymers through chemical interaction or grafting into the main chain structure of raw materials to enhance their therapeutic effects, are essential to meet the high standards of biomedical features. Another way to improve the mechanical and thermal properties is to graft appropriate fillers onto the polysaccharide backbone. The characteristics of polysaccharide bio-nanocomposites in comparison to more traditional polymers have attracted a lot of interest. With an emphasis on anti-inflammatory, anticancer, antiviral, immunoregulatory, and anticoagulant properties, this review delves into the most recent biological uses of sulfated polysaccharides. As well as thoroughly outlining the factors that impact the biological properties, such as the extraction process, molecular weight (Mw), the degree of sulfation, distribution/position, modification procedures, and the filler size,
etc.
, this review aims to: (1) provide a systematic and critical overview of the cutting-edge research on SPs and hybrid sulfated polysaccharide bio-nanocomposites; (2) identify the key factors, mechanisms, methods, and challenges impacting SPs bio-nanocomposites; (3) elucidate the current and potential biomedical applications, advantages, manufacturing challenges, and opportunities associated with SPs bio-nanocomposites; (4) offer insights into future research directions by suggesting improvements for bio-nanocomposites, including novel materials, and advanced processing techniques.
The work provides a systematic and critical overview of the cutting-edge research on SPs and hybrid sulfated polysaccharide bio-nanocomposites and identifies the key factors, mechanisms, methods, and challenges impacting SPs bio-nanocomposites. |
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| Bibliography: | 2 M. A. Hussein is a professor of Polymer Chemistry, Polymer Chemistry Lab, Chemistry Department, Faculty of Science, Assiut University (AU), Egypt. He obtained his PhD in Organic Polymer Synthesis from Assiut University, Egypt in 2007. He has held a position at Chemistry Department, King Abdulaziz University (KAU), Jeddah, Saudi Arabia since 2010. He had postdoctoral positions in the University of Nice Sophia Antipolis, France and University Sains Malaysia, Malaysia. He visited the School of Industrial Technology, University Sains Malaysia and Faculty of Engineering, University of Porto (UP) as a visiting researcher. He published 268 ISI papers and numerous conference papers (posters and oral). His research interests are in the area of polymer synthesis, characterization and applications in different fields, polymer composites materials, polymer-doped organic and/or inorganic substances for various industrial as well as biological applications. Her PhD research focuses on the synthesis, characterization, and development of hybrid bio-nanocomposites based on polysaccharides for multiple applications. K. A. Alamry is a professor of Polymer Chemistry, at Chemistry Department, Faculty of Science, King Abdulaziz University (KAU), Jeddah, Saudi Arabia. He obtained his PhD in Polymer Chemistry from The University of Manchester in UK in 2010. He has published 377 ISI papers in the field of polymers. His research interest is focused on biopolymers from synthesis to various applications. Reem S. Alfinaikh is a PhD candidate in the Chemistry Department at King Abdulaziz University (KAU), Jeddah, Saudi Arabia. She obtained her Master's degree in Chemistry from Clark Atlanta University in the USA in 2017. Her interest in nanocomposite materials started with her master's work on poly(ethylene oxide) and SiO ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 2046-2069 2046-2069 |
| DOI: | 10.1039/d4ra07277d |