Serum leptin levels during childhood and adolescence: relationship with age, sex, adiposity and puberty

We studied serum leptin levels in 189 healthy children to evaluate related factors during childhood and adolescence. Leptin correlated with body mass index (BMI), triceps skinfold thickness (p<0.001) and body weight (p<0.01). Obese children and girls had higher leptin levels than non-obese chi...

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Bibliographic Details
Published inTurkish journal of pediatrics Vol. 41; no. 4; pp. 447 - 455
Main Authors Kirel, B, Doğruel, N, Akgün, N, Kiliç, F S, Tekin, N, Uçar, B
Format Journal Article
LanguageEnglish
Published Turkey Türk Pediatri Derneği 01.10.1999
Subjects
Adolescence
Adolescent
Adult
Age Factors
Amino acids, peptides and proteins
Aminoasitler, peptidler ve proteinler
Body Mass Index
Child
Child, Preschool
Childhood
Cinsiyet faktörleri
Ergenlik
Ergenlik çağı
Erişkin
Female
Fizyolojik süreçler
Hormones, hormone substitutes and hormone antagonists
Hormonlar, hormon substitütleri ve hormon antagonistleri
Humans
Infant
Leptin
Leptin - blood
Male
Obesity
Obezite
Physiological processes
Puberty
Puberty - blood
Reproductive and urinary physiology
Sex Factors
Skinfold Thickness
Somatotypes
Süt çocuğu
Vücut kütle indeksi
Yaş faktörleri
Çocuk, okul öncesi
Çocukluk çağı
Üreme ve üriner sistem fizyolojisi
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Summary:We studied serum leptin levels in 189 healthy children to evaluate related factors during childhood and adolescence. Leptin correlated with body mass index (BMI), triceps skinfold thickness (p<0.001) and body weight (p<0.01). Obese children and girls had higher leptin levels than non-obese children and boys, respectively (p<0.001). In girls, leptin correlated positively with age, skinfold thickness and BMI (p<0.001). In boys, leptin correlated negatively with age (p<0.001) and positively with skinfold thickness (p<0.05). Prepubertal boys had higher leptin levels than prepubertal girls and pubertal boys (p<0.05). Pubertal girls had higher leptin levels than prepubertal girls and pubertal boys (p<0.001). Leptin levels in girls were higher at Tanner stages 4 and 5 than at stage 1 (p<0.001). In conclusion, serum leptin levels are related with adiposity, have obviously age-related gender differences during childhood and adolescence, and may be involved in the maturation of reproductive capacity.
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ISSN:0041-4301