Unusual Association of Large Cell Neuroendocrine Carcinoma of the Bladder and Prostatic Adenocarcinoma Within a 76-Year-Old Man

Large cell neuroendocrine carcinoma (LCNEC) is one of the rarest types of bladder cancer, with an aggressive course and a poor prognosis. We report a case of LCNEC of the bladder associated with a prostatic adenocarcinoma. A very rare association, to our knowledge, is described for the first time in...

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Published inCurēus (Palo Alto, CA) Vol. 16; no. 8; p. e67651
Main Authors Nassira, Karich, Aberkane, Mahmoud, El Moudane, Anouar, Haloui, Anass, Bennani, Amal
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 24.08.2024
Cureus
Subjects
Bladder
Cancer therapies
Case reports
Chemotherapy
Endocrine therapy
Hematuria
Hospitals
Medical imaging
Medical prognosis
Medicine
Metastasis
Neuroendocrine tumors
Oncology
Pathology
Patients
Pharmacy
Prostate
Radiation therapy
Surgery
Urology
urinary tumor
prostatic adenocarcinoma
bladder cancer
large cell neuroendocrine carcinoma
surgery
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Summary:Large cell neuroendocrine carcinoma (LCNEC) is one of the rarest types of bladder cancer, with an aggressive course and a poor prognosis. We report a case of LCNEC of the bladder associated with a prostatic adenocarcinoma. A very rare association, to our knowledge, is described for the first time in the literature. The patient was a 76-year-old non-smoker male, who presented with intermittent hematuria and dysuria. Cystoscopy revealed a lesion on the right lateral bladder wall. Biopsy was in favor of a LCNEC with muscle invasion. The CT scan showed the presence of a second lesion in the prostate, confirmed by histological examination. The patient was treated by neoadjuvant chemotherapy of the cisplatin-etoposide type for large-cell bladder neuroendocrine carcinoma, and hormone therapy with luteinizing hormone-releasing hormone (LH-RH) analogs for prostatic adenocarcinoma, followed by radical surgery. Given the rarity of this tumor, LCNEC treatment lacks precision. Many cases are published with different therapeutic strategies. A literature review would be interesting to codify the therapeutic strategy for this rare tumor.
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.67651