Deep Photoacoustic/Luminescence/Magnetic Resonance Multimodal Imaging in Living Subjects Using High‐Efficiency Upconversion Nanocomposites

A gadolinium‐doped multi‐shell upconversion nanoparticle under 800 nm excitation is synthesized with a 10‐fold fluorescence‐intensity enhancement over that under 980 nm. The nanoformulations exhibit excellent photoacoustic/luminescence/magnetic resonance tri‐modal imaging capabilities, enabling visu...

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Published inAdvanced materials (Weinheim) Vol. 28; no. 30; pp. 6411 - 6419
Main Authors Liu, Yu, Kang, Ning, Lv, Jing, Zhou, Zijian, Zhao, Qingliang, Ma, Lingceng, Chen, Zhong, Ren, Lei, Nie, Liming
Format Journal Article
LanguageEnglish
Published Germany 01.08.2016
Subjects
deep imaging
high‐efficiency upconversion luminescence
Imaging
Luminescence
Magnetic resonance
magnetic resonance imaging
multi‐shell structure
Nanocomposites
Nanostructure
photoacoustic (PA) imaging
Tumors
Upconversion
Visualization
deep imaging
multi-shell structure
high-efficiency upconversion luminescence
magnetic resonance imaging
photoacoustic (PA) imaging
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Summary:A gadolinium‐doped multi‐shell upconversion nanoparticle under 800 nm excitation is synthesized with a 10‐fold fluorescence‐intensity enhancement over that under 980 nm. The nanoformulations exhibit excellent photoacoustic/luminescence/magnetic resonance tri‐modal imaging capabilities, enabling visualization of tumor morphology and microvessel distribution at a new imaging depth.
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ISSN:0935-9648
1521-4095
1521-4095
DOI:10.1002/adma.201506460