Vitamin D inadequacy in pregnancy: biology, outcomes, and interventions

A high prevalence of maternal vitamin D inadequacy during pregnancy and at delivery has been demonstrated in various ethnic populations living at different latitudes. Because placental transfer of 25(OH)D is the major source of vitamin D to the developing human fetus, there is growing concern about...

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Bibliographic Details
Published inNutrition reviews Vol. 68; no. 8; pp. 465 - 477
Main Authors Dror, Daphna K, Allen, Lindsay H
Format Journal Article
LanguageEnglish
Published Malden, USA Blackwell Publishing Inc 01.08.2010
Oxford University Press
Subjects
Adaptation, Physiological
Bone Density Conservation Agents - metabolism
Bone Density Conservation Agents - therapeutic use
Dietary Supplements
Female
Humans
inadequacy
Intervention
Maternal & child health
Maternal Nutritional Physiological Phenomena - physiology
Nutrition Policy
Nutritional Requirements
Pregnancy
Pregnancy Complications - epidemiology
Pregnancy Complications - prevention & control
Pregnancy Outcome
Prenatal care
Prenatal Nutritional Physiological Phenomena - physiology
Public Health
Risk factors
Treatment Outcome
Vitamin D
Vitamin D - metabolism
Vitamin D - therapeutic use
Vitamin D Deficiency - epidemiology
Vitamin D Deficiency - prevention & control
Vitamin deficiency
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Summary:A high prevalence of maternal vitamin D inadequacy during pregnancy and at delivery has been demonstrated in various ethnic populations living at different latitudes. Because placental transfer of 25(OH)D is the major source of vitamin D to the developing human fetus, there is growing concern about adverse health impacts that hypovitaminosis D during pregnancy may have on the mother as well as the offspring in utero, in infancy, and later in life. While there is lack of consensus regarding the optimal circulating 25(OH)D concentration in pregnancy, it is evident that prior levels used to establish intake recommendations and vitamin D content of prenatal vitamin supplements were too conservative. This review summarizes vitamin D metabolism in the perinatal period, examines evidence regarding outcomes of insufficiency in the mother and offspring, discusses risk factors and prevalence of insufficiency, and considers strategies for public health intervention.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0029-6643
1753-4887
DOI:10.1111/j.1753-4887.2010.00306.x