Central tolerance induction

A critical function of the thymus is to help enforce tolerance to self. The importance of central tolerance in preventing autoimmunity has been enlightened by a deeper understanding of the interactions of developing T cells with a diverse population of thymic antigen presenting cell populations. Fur...

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Bibliographic Details
Published inCurrent topics in microbiology and immunology Vol. 373; p. 69
Main Authors Mouchess, Maria L, Anderson, Mark
Format Journal Article
LanguageEnglish
Published Germany 01.01.2014
Subjects
Animals
Antigen-Presenting Cells - physiology
Central Tolerance
Humans
T-Lymphocytes - immunology
T-Lymphocytes, Regulatory - immunology
Thymus Gland - immunology
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Summary:A critical function of the thymus is to help enforce tolerance to self. The importance of central tolerance in preventing autoimmunity has been enlightened by a deeper understanding of the interactions of developing T cells with a diverse population of thymic antigen presenting cell populations. Furthermore, there has been rapid progress in our understanding of how autoreactive T cell specificities are diverted into the T regulatory lineage. Here we review and highlight the recent progress in how tolerance is imposed on the developing thymocyte repertoire.
ISSN:0070-217X
DOI:10.1007/82_2013_321