Electrochemical trifluoroalkylation/annulation for the synthesis of CF3-functionalized tetrahydroquinolines and dihydroquinolinones

Tuning the electronic structure of protecting groups on the nitrogen atom of substrates has emerged as an effective strategy to achieve the tandem trifluoromethylation/C(sp(2))-H annulation using Langlois' reagent as the CF3 source for the electrochemical synthesis of functionalized tetrahydroq...

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Published inOrganic & biomolecular chemistry Vol. 21; no. 42; pp. 8579 - 8583
Main Authors Wu, Hao-Zeng, Teng, Zhong-Shan, Ke, Yu-Xin, Zou, Yu, Gao, Ping, Li, Yue, Zhou, Cheng-He, Zang, Zhong-Lin
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.11.2023
Royal Society of Chemistry
Subjects
Chemical reactions
Chemical synthesis
Chemistry
Chemistry, Organic
Electrochemistry
Electronic structure
Organic chemistry
Physical Sciences
Protecting groups
Reagents
Science & Technology
Substrates
FUNCTIONALIZATION
DIFUNCTIONALIZATION
ALKENES
CATALYSIS
HYDROGENATION
LEWIS-ACID
STRATEGY
QUINOLINES
CASCADE
TRIFLUOROMETHYLATION
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Summary:Tuning the electronic structure of protecting groups on the nitrogen atom of substrates has emerged as an effective strategy to achieve the tandem trifluoromethylation/C(sp(2))-H annulation using Langlois' reagent as the CF3 source for the electrochemical synthesis of functionalized tetrahydroquinolines and dihydroquinolinones.
Bibliography:ObjectType-Article-1
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ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
DOI:10.1039/d3ob00987d