Synthesis and spectroscopic characterisation of novel roflumilast analogues

A series of new N-heterocyclic or phenoxy substituted roflumilast analogues have been designed and synthesised. N-heterocyclic or phenoxy substituted benzaldehydes were first prepared from 3-hydroxy-4-methoxybenzaldehbyde and 1-bromo-3-chloropropane by an alkylation reaction. The roflumilast analogu...

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Bibliographic Details
Published inJournal of chemical research Vol. 37; no. 10; pp. 583 - 585
Main Authors Sun, Gangchun, Si, Yuhui, Song, Ge, Mai, Wenpeng, Li, Zhicheng
Format Journal Article
LanguageEnglish
Published LONDON Sage 01.10.2013
Sage Publications Ltd
Subjects
Acylation
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
roflumilast analogue
3-hydroxy-4-methoxybenzaldehyde
DISEASE
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Summary:A series of new N-heterocyclic or phenoxy substituted roflumilast analogues have been designed and synthesised. N-heterocyclic or phenoxy substituted benzaldehydes were first prepared from 3-hydroxy-4-methoxybenzaldehbyde and 1-bromo-3-chloropropane by an alkylation reaction. The roflumilast analogues were then obtained by oxidation, acylation, amidation and alkylation reactions. These compounds were characterised by H-1 NMR, IR, ESI-MS and elemental analyses.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1747-5198
2047-6507
DOI:10.3184/174751913X13782291519608