Synthesis of 2,2-difunctionalized 2H-azirines via I2-mediated annulation of enamines

Various 2,2-difunctionalized 2H-azirines were synthesized via I-2-mediated annulation reactions of readily accessible enamines in the presence of nitrogen or non-nitrogen nucleophiles. The features of the present synthesis process also include no use of transition metals, simple operation, mild reac...

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Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 22; no. 11; pp. 2292 - 2299
Main Authors Lu, Qing, He, Yanmin, Chang, Junbiao, Yu, Wenquan
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 13.03.2024
Royal Society of Chemistry
Subjects
Chemical reactions
Chemical synthesis
Chemistry
Chemistry, Organic
Nitrogen
Nucleophiles
Organic chemistry
Physical Sciences
Science & Technology
Substrates
Transition metals
C BOND FORMATION
INDOLES
ENAMIDES
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Summary:Various 2,2-difunctionalized 2H-azirines were synthesized via I-2-mediated annulation reactions of readily accessible enamines in the presence of nitrogen or non-nitrogen nucleophiles. The features of the present synthesis process also include no use of transition metals, simple operation, mild reaction conditions, a broad substrate scope, and gram-scale synthesis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
DOI:10.1039/d4ob00156g