The B cell antigen CD75 is a cell surface sialyltransferase

In this work we have isolated a cDNA clone encoding the B cell antigen CD75. The amino acid sequence of CD75 is shown to be identical to that of human alpha 2,6 sialyltransferase, believed to be primarily associated with the Golgi complex. This is the first demonstration of cell surface expression o...

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Published inThe Journal of experimental medicine Vol. 172; no. 2; pp. 641 - 643
Main Authors STAMENKOVIC, I, ASHEIM, H. C, DEGGERDAL, A, BLOMHOFF, H. K, SMELAND, E. B, FUNDERUD, S
Format Journal Article
LanguageEnglish
Published New York, NY Rockefeller University Press 01.08.1990
Subjects
Biological and medical sciences
CD75 antigen
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immunobiology
lymphocytes B
Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation
sialyltransferase
Antigen
Human
Complementary DNA
RNA
Nucleotide sequence
Enzyme
Transferase
Blotting assay
B-Lymphocyte
Cell surface
Comparative study
Aminoacid sequence
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Summary:In this work we have isolated a cDNA clone encoding the B cell antigen CD75. The amino acid sequence of CD75 is shown to be identical to that of human alpha 2,6 sialyltransferase, believed to be primarily associated with the Golgi complex. This is the first demonstration of cell surface expression of sialyltransferase which, in B cells, may play an important role in intercellular adhesion and antigen presentation events.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.172.2.641