Non-surgical periodontal treatment improves rheumatoid arthritis disease activity: a meta-analysis

• Published in: Clinical oral investigations Vol. 25; no. 8; pp. 4975 - 4985
• Main Authors: Sun, Jia, Zheng, Youli, Bian, Xiaowei, Ge, Huijian, Wang, Jun, Zhang, Zheng
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2021; Springer Nature B.V
• Subjects: Arthritis, Rheumatoid - therapy; C-Reactive Protein; Dentistry; Erythrocyte sedimentation rate; Gum disease; Humans; Interleukin 6; Medicine; Meta-analysis; Original Article; Patients; Periodontitis; Rheumatoid arthritis; Rheumatoid Factor; Statistical analysis; Tumor Necrosis Factor-alpha; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Treatment; Disease activity; Periodontitis; Rheumatoid arthritis; Meta-analysis
• ISSN: 1432-6981; 1436-3771
• DOI: 10.1007/s00784-021-03807-w

Objectives The aim of the meta-analysis was to clarify the efficacy of non-surgical periodontal treatment (NSPT) in improving rheumatoid arthritis (RA) disease activity. Methods A systematic literature search was conducted using the PubMed, Embase, and Cochrane databases up to October 2020. A total of nine studies were included for the comparison of RA-related indicator changes between the NSPT group and no treatment (NT) group. Mean differences (MD) and 95% confidence intervals (CI) were calculated for disease activity score (DAS28), erythrocyte sedimentation rate (ESR), tender joint counts (TJC), swollen joint counts (SJC), visual analogical scale (VAS), morning stiffness (MS), rheumatoid factor (RF), C-reactive protein (CRP), tumor necrosis factor α (TNF-α), and interleukin-6 (IL-6). Results NSPT induced significant reductions of DAS28 (MD: 0.61, 95% CI: 0.37, 0.85, P < 0.001), TJC (MD: 0.65, 95% CI: 0.37, 0.93, P < 0.001), SJC (MD: 0.67, 95% CI: 0.18, 1.17, P = 0.008), VAS (MD: 0.48, 95% CI: 0.08, 0.88, P = 0.02), and CRP (MD: 0.34, 95% CI: 0.07, 0.64, P = 0.01) in RA patients with periodontitis. Other parameters showed a trend toward reduction, but results were not statistically significant. Conclusions This meta-analysis indicates that NSPT could improve RA activity as assessed by DAS28, TJC, SJC, VAS, and CRP. Clinical relevance The results emphasize the effectiveness and need for periodontal diagnosis and periodontal therapy in rheumatoid arthritis patients to reduce disease activity.