Characteristic of the complement system in patients with ischemic heart disease with moderate and marked hemolysis after operations with cardiopulmonary bypass

• Published in: Kardiologiia Vol. 53; no. 2; p. 4
• Main Authors: Chumakova, S P, Urazova, O I, Novitskiĭ, V V, Shipulin, V M, Khokhlov, O A, Emel'ianova, T V, Mikhaĭlova, M A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2013
• Subjects: Cardiopulmonary Bypass - adverse effects; Cardiopulmonary Bypass - methods; CD55 Antigens - metabolism; Complement Membrane Attack Complex - analysis; Complement Membrane Attack Complex - metabolism; Complement Pathway, Alternative; Coronary Artery Bypass - methods; Erythrocytes - immunology; Female; Hemoglobinometry; Hemolysis - immunology; Humans; Male; Middle Aged; Myocardial Ischemia - blood; Myocardial Ischemia - surgery; Receptors, Complement 3b - metabolism; Reticulocyte Count; Severity of Illness Index
• ISSN: 0022-9040

A study of the complement system in cardiosurgical patients with moderate (40 patients) and marked (18 patients) hemolysis after coronary artery bypass grafting in conditions of cardiopulmonary bypass was carried out. Before and after operation the content of D35+-, D55+-erythrocytes and reticulocytes in blood, free hemoglobin in blood plasma, indicators of the functional state of classical, lectin and alternative pathways of complement activation as well as concentration of its terminal complex in blood serum were analyzed. It was established that development of marked hemolysis was associated with higher (compared with moderate hemolysis) content of terminal complement complex and reticulocytes in blood before operation as well as deficiency of D55+- erythrocytes and low activity of alternative pathway.