Elevated serum matrix metalloproteinase-2 and -9 and their correlations with severity of disease in patients with community-acquired pneumonia

• Published in: Turkish journal of medical sciences Vol. 45; no. 3; pp. 593 - 599
• Main Authors: Bircan, Hacı Ahmet, Çakir, Münire, Yilmazer Kapulu, Ilkay, Sütcü, Recep, Kaya, Selçuk, Öztürk, Onder
• Format: Journal Article
• Language: English
• Published: Turkey 2015
• Subjects: Adult; Aged; Anti-Bacterial Agents - therapeutic use; Community-Acquired Infections - blood; Community-Acquired Infections - drug therapy; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Matrix Metalloproteinase 2 - blood; Matrix Metalloproteinase 9 - blood; Pneumonia - blood; Pneumonia - drug therapy; Severity of Illness Index
• ISSN: 1300-0144
• DOI: 10.3906/sag-1402-51

To determine the role of matrix metalloproteinases (MMPs) and their relationship with the clinical course of community-acquired pneumonia (CAP). Sixty-two consecutively hospitalized patients with CAP were enrolled and their pneumonia severity index (PSI), time to clinical stability (TCS), treatment response, and complications were recorded. The pre- and posttreatment serum concentrations of MMPs and their inhibitors were analyzed by ELISA. The activities of MMPs were evaluated by gelatin zymography. MMP-2 and -9 serum levels and their activities were higher in CAP patients than controls (P < 0.001 and P < 0.001, respectively). Low-risk patients had lower levels of MMP-2 and TIMP-1 than high-risk patients (P = 0.044, P = 0.001, respectively). Pretreatment serum TIMP-1 level was higher in patients with TCS of >3 days (P = 0.004) and was correlated with oxygenation and PSI scores. Posttreatment serum levels of MMP-9 and TIMP-1 were decreased after antibiotics (P = 0.000 1 and P = 0.0 17, respectively). Although MMP-2, MMP-9, and TIMP-1 correlate with many poor prognostic factors, more studies are required to prove their possible role in predicting the severity of CAP.