Mucormycosis in Liver Allograft Following Transplant for Secondary Biliary Cirrhosis

• Published in: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation Vol. 22; no. 4; pp. 314 - 317
• Main Authors: Parmentier, Catherine, Cruz-Martínez, Rodrigo, Quintero-Quintero, Marco J, Vilatobá, Mario
• Format: Journal Article
• Language: English
• Published: Turkey 01.04.2024
• Subjects: Allografts; Amphotericin B - administration & dosage; Amphotericin B - therapeutic use; Antifungal Agents - therapeutic use; Debridement; Fatal Outcome; Hepatectomy; Humans; Immunocompromised Host; Liver Cirrhosis, Biliary - diagnosis; Liver Cirrhosis, Biliary - microbiology; Liver Cirrhosis, Biliary - surgery; Liver Transplantation - adverse effects; Male; Middle Aged; Mucormycosis - diagnosis; Mucormycosis - drug therapy; Mucormycosis - etiology; Mucormycosis - immunology; Mucormycosis - microbiology; Multiple Organ Failure - etiology; Multiple Organ Failure - microbiology; Opportunistic Infections - diagnosis; Opportunistic Infections - drug therapy; Opportunistic Infections - immunology; Opportunistic Infections - microbiology; Treatment Outcome
• ISSN: 2146-8427
• DOI: 10.6002/ect.2023.0142

Mucormycosis, a group of opportunistic mycoses caused by Mucorales, present a significant threat to immunocompromised patients. In this report, we present the case of a 57-year-old male patient who underwent liver transplant for secondary biliary cirrhosis following inadvertent bile duct injury. Despite initial satisfactory postoperative evolution, the patient developed fever, and imaging revealed a suspicious lesion. Preliminary culture growth suggested a filamentous fungus, leading to initiation of liposomal amphotericin B. However, the lesion progressed, and a surgical debridement was necessary. During surgery, involvement of the liver dome and diaphragm was observed, and a nonanatomical hepatectomy was performed. Despite efforts, the patient's condition deteriorated, ultimately resulting in multiple organ failure and mortality. This case emphasizes the challenging nature of mucormycosis in livertransplant recipients.