The effects of silodosin therapy on the parameters and patterns of ureteric jets in patients with lower urinary tract symptoms

• Published in: European review for medical and pharmacological sciences Vol. 27; no. 6; p. 2320
• Main Authors: Salman, M Y, Murzoglu Altintoprak, K, Kuzan, T Y, Bayar, G, Sinanoglu, O
• Format: Journal Article
• Language: English
• Published: Italy 01.03.2023
• Subjects: Adrenergic alpha-1 Receptor Antagonists - therapeutic use; Humans; Indoles - therapeutic use; Lower Urinary Tract Symptoms - drug therapy; Male; Prospective Studies; Prostatic Hyperplasia - drug therapy; Ureter
• ISSN: 2284-0729
• DOI: 10.26355/eurrev_202303_31766

To our knowledge, there is no study in the literature so far to investigate the effect of silodosin therapy on the ureteric jet parameters. Therefore, the objective of this study was to investigate the effect of silodosin 8 mg/day for medical therapy of lower urinary tract symptoms (LUTS) on the color flow Doppler parameters and patterns of the ureteric jets. This prospective cohort study included 34 male patients who presented to our outpatient clinic with the complaint of lower urinary tract symptoms (LUTS) and received silodosin 8 mg once a day as medical therapy. In the color flow Doppler examinations, ureteric jets were observed and mean flow rate (JETave), maximum flow rate (JETmax), flow duration (JETdura), and flow frequency (JETfre) were examined. In addition, patterns of the ureteric jets (JETpat) were also evaluated. There was no statistically significant difference in JETave; however, JETmax, JETdura and JETfre were significantly higher at post-silodosin treatment. The patterns of ureteric jet were significantly changed following a 6-week treatment with silodosin (p<0.001). One ureter in the monophasic pattern group (9.1%) and three in the biphasic group (13.6%) turned to polyphasic pattern after silodosin use. None of the patients developed side effects that would require discontinuation of the drug. Six-week silodosin 8 mg/day therapy for the treatment of LUTS in men changed the parameters and patterns of ureteric jets at follow-up examination. Furthermore, comprehensive studies are needed on this issue.