Epstein-Barr virus infection or malignant lymphoma - what you see is not what you get

Infectious mononucleosis may mimic lymphoma, both clinically and histopathologically. We present a patient with neurological symptoms and lymphadenopathy, initially diagnosed as Epstein-Barr virus (EBV)-positive angioimmunoblastic T-cell lymphoma (AITL) with cerebrospinal fluid (CSF) localisation ba...

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Published inNetherlands journal of medicine Vol. 77; no. 10; pp. 370 - 372
Main Authors de Haes, I, Versluis, J, Lam, K H, Jongen, J L M, Doorduijn, J K, Kuipers, S
Format Journal Article
LanguageEnglish
Published Netherlands 01.12.2019
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Summary:Infectious mononucleosis may mimic lymphoma, both clinically and histopathologically. We present a patient with neurological symptoms and lymphadenopathy, initially diagnosed as Epstein-Barr virus (EBV)-positive angioimmunoblastic T-cell lymphoma (AITL) with cerebrospinal fluid (CSF) localisation based on lymph node pathology and a 30-fold higher EBV load in the CSF compared with serum. However, the patient fully recovered spontaneously and EBV became negative in both CSF and serum, suggestive of a dramatic presentation of EBV meningoencephalitis.
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ISSN:1872-9061