Sex Differences in Behavioral Reactions and the Character of Audiogenic Seizures in Krushinsky-Molodkina Rat Strain

• Published in: Zurnal vyss̆ej nervnoj dejatelnosti imeni I P Pavlova Vol. 65; no. 6; p. 756
• Main Authors: Krivopalov, S A, Yushkov, B G
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.11.2015
• Subjects: Animals; Anxiety - physiopathology; Epilepsy, Reflex - physiopathology; Female; Male; Motor Activity - physiology; Rats; Sex Characteristics
• ISSN: 0044-4677
• DOI: 10.7868/s0044467715050068

In the "open field" test it was found that locomotor activity in Krushinsky-Molodkina rat strain (KM) is higher than in nonlinear animals. At the same time, both groups of animals had the same sex differences: a locomotor activity of females was higher than males. Sex differences in exploratory activities are not inherent for KM rats, while the female outbred animals are significantly higher than males in their level of such activities. The greatest differences in behavior between KM rats and outbred animals were found in anxiety level, which is much higher in the first case. Furthermore just KM rats are characterized by clear sex differences--the males demonstrate more anxious and fearful respond to unfamiliar surroundings than females. Male and female KM rats differ not only in behavior but also in the character of epileptiform seizures induced by loud sound: wild running, tonic-clonic and clonic convulsions occur faster in females and the resumption of breathing-in males. The interconnection between parameters of seizure and behavior was found for KM rats. This phenomenon is most clearly manifested in males and combine large group of indicators.