Janus kinase inhibition as a potential strategy for the treatment of psoriasis: state of the art and future perspectives

Research is focusing the attention on drugs acting on intracellular signaling as a possible strategy for various malignancies and autoimmune disorders, as well as prevention of transplant rejection. In such a context, an intriguing therapeutic target appears to be the signaling pathway mediated by J...

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Bibliographic Details
Published inJournal of biological regulators and homeostatic agents Vol. 26; no. 4; p. 587
Main Authors Cassano, N, Vena, G A
Format Journal Article
LanguageEnglish
Published Italy 01.10.2012
Subjects
Humans
Janus Kinases - antagonists & inhibitors
Piperidines
Protein Kinase Inhibitors - therapeutic use
Psoriasis - drug therapy
Psoriasis - enzymology
Pyrazoles - therapeutic use
Pyrimidines - therapeutic use
Pyrroles - therapeutic use
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Summary:Research is focusing the attention on drugs acting on intracellular signaling as a possible strategy for various malignancies and autoimmune disorders, as well as prevention of transplant rejection. In such a context, an intriguing therapeutic target appears to be the signaling pathway mediated by Janus kinases (JAK)/signal transducers and activators of transcription (STAT) protein family. Several companies are developing and evaluating JAK inhibitors for immune-mediated disorders, including psoriasis. Among these drugs, ruxolitinib and especially tofacitinib have reached more advanced phases of clinical and experimental development. This review discusses the potential role of JAK inhibition in the treatment of psoriasis and presents the preliminary data regarding the clinical development of JAK inhibitors in this disease.
ISSN:0393-974X